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采用无溶剂-顶空-气相色谱直接测定盐酸左氧氟沙星中残留溶剂乙醇、甲苯、二甲基亚砜(DMSO)等。各残留溶剂的检出限分别在0.007-0.032μg,6次测定的相对标准偏差RSD在1.84%-1.92%,加标回收在90.9%-110%。方法简便、快速、灵敏,可应用于其他药品中残留溶剂的分析。
Solvent-free headspace-gas chromatography was developed for the direct determination of residual solvents such as ethanol, toluene and dimethylsulfoxide (DMSO) in levofloxacin hydrochloride. The detection limits of each residual solvent were 0.007-0.032μg, respectively. The relative standard deviations (RSDs) of six determinations were between 1.84% and 1.92%, and the recoveries were between 90.9% and 110%. The method is simple, rapid and sensitive and can be applied to the analysis of residual solvents in other drugs.