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目的探讨PINCH蛋白和环氧化酶-2(COX-2)蛋白在子宫内膜癌中的表达及其临床意义。方法采用免疫组化ABC法检测23例正常子宫内膜、18例不典型增生子宫内膜和50例子宫内膜癌中PINCH蛋白和COX-2蛋白的表达,并分析其临床意义。结果 PINCH蛋白在正常子宫内膜、不典型增生子宫内膜和子宫内膜癌间质中的阳性表达率分别为17.4%、38.8%、72.0%,呈现逐渐增高的趋势,差异有统计学意义(P<0.05);COX-2蛋白在正常子宫内膜、不典型增生子宫内膜和子宫内膜癌上皮中的阳性表达率分别为26.1%、61.1%、80.0%,呈现逐渐增高的趋势,差异有统计学意义(P<0.05)。PINCH蛋白及COX-2蛋白阳性表达率与子宫内膜癌的分期、淋巴结转移、组织学类型、肌层浸润深度、病理分级等无明显相关性(P>0.05),PINCH蛋白的表达与雌激素作用时间有关(P<0.05)。PINCH蛋白与COX-2蛋白的表达呈正相关(r=0.468,P<0.05)。结论 PINCH、COX-2与子宫内膜癌的发生相关,在子宫内膜癌中二者表达有明显相关性,为肿瘤基因治疗提供新的靶点。
Objective To investigate the expression of PINCH protein and cyclooxygenase-2 (COX-2) protein in endometrial carcinoma and its clinical significance. Methods Immunohistochemical ABC method was used to detect the expression of PINCH protein and COX-2 protein in 23 cases of normal endometrium, 18 cases of atypical hyperplasia and 50 cases of endometrial carcinoma. The clinical significance was analyzed. Results The positive expression rates of PINCH protein in normal endometrium, atypical endometrial and endometrial carcinoma were 17.4%, 38.8%, 72.0%, respectively, showing a trend of increasing gradually with a significant difference ( P <0.05). The positive expression rates of COX-2 protein in normal endometrium, atypical hyperplasia endometrium and endometrial carcinoma epithelium were 26.1%, 61.1% and 80.0%, respectively, showing an increasing trend, the difference was statistically significant There was statistical significance (P <0.05). The positive rate of PINCH protein and COX-2 protein had no significant correlation with the stage of staging, lymph node metastasis, histological type, depth of myometrial invasion, pathological grade, etc. (P> 0.05). The positive expression of PINCH protein correlated with estrogen The role of time (P <0.05). PINCH protein and COX-2 protein expression was positively correlated (r = 0.468, P <0.05). Conclusions PINCH and COX-2 are correlated with the occurrence of endometrial carcinoma. The expression of PINCH and COX-2 in endometrial carcinoma has a significant correlation, providing a new target for gene therapy of cancer.