目的:探讨子宫内膜癌组织中γ-synuclein、C-erbB-2的表达及其与疾病的临床病理特征的关系。方法:采用免疫组化SP法检测60例子宫内膜癌中γ-synuclein、C-erbB-2的表达情况,并分析其与肿瘤分期、组织病理学分级、淋巴结转移、浸润深度等病理特征的关系,同时取12例正常子宫内膜组织作对照。结果:子宫内膜癌组织中γ-synuclein、C-erbB-2阳性表达率分别为48.3%(29/60)、55.0%(33/60),与对照组比较差异有统计学意义(P<0.05)。γ-synuclein的阳性表达与临床分期、肌层浸润深度及淋巴结转移有关(P<0.05),与组织学分级无关(P>0.05);C-erbB-2的阳性表达与临床分期、肌层浸润深度有关(P<0.05),与组织学分级、淋巴结转移无关(P>0.05)。γ-synuclein、C-erbB-2的阳性表达之间呈正相关(r=0.406,P<0.05)。结论:γ-synuclein、C-erbB-2的表达与子宫内膜癌发生、发展及侵袭、转移有关,二者共同检测可能可预测子宫内膜癌的预后。 Objective: To investigate the expression of γ-synuclein and C-erbB-2 in endometrial carcinoma and its relationship with clinicopathological features. Methods: The expressions of γ-synuclein and C-erbB-2 in 60 cases of endometrial carcinoma were detected by immunohistochemical SP method. The expressions of γ-synuclein and C-erbB-2 were analyzed with the pathological features of tumor staging, histopathological grade, lymph node metastasis and depth of invasion Relationship, while taking 12 cases of normal endometrial tissue as a control. Results: The positive rates of γ-synuclein and C-erbB-2 in endometrial carcinoma were 48.3% (29/60) and 55.0% (33/60), respectively, which were significantly different from those in control group (P < 0.05). The positive expression of γ-synuclein was correlated with clinical stage, depth of myometrial invasion and lymph node metastasis (P <0.05), but not with histological grade (P> 0.05). The positive expression of C-erbB-2 was correlated with clinical stage, Depth (P <0.05), but not with histological grade and lymph node metastasis (P> 0.05). γ-synuclein, C-erbB-2 positive expression was positively correlated (r = 0.406, P <0.05). Conclusions: The expression of γ-synuclein and C-erbB-2 is related to the occurrence, development, invasion and metastasis of endometrial carcinoma. The combination of them may predict the prognosis of endometrial carcinoma.