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运用免疫组织化学方法研究原发性肺癌中P53蛋白过表达的临床病理意义。结果发现112例肺癌中有50例表达P53蛋白（45％），鳞癌中的表达率明显高于腺癌，分别为59％和32％（P＜0.05）。伴淋巴结转移的肺癌P53蛋白表达率为46％，明显高于无淋巴结转移的肺癌组（37％，P＜0．05）。结果提示不同组织学类型的肺癌发生学机制可能不同，而且P53蛋白表达状态可能也是估计肺癌预后的一个重要参数。
Immunohistochemistry was used to study the clinicopathological significance of P53 protein overexpression in primary lung cancer. The results showed that 50 of 112 lung cancers expressed P53 protein (45%), and the expression rate in squamous cell carcinoma was significantly higher than that in adenocarcinoma, which was 59% and 32%, respectively (P<0.05). The rate of P53 protein expression in lung cancer with lymph node metastasis was 46%, which was significantly higher than that of lung cancer without lymph node metastasis (37%, P<0.05). The results suggest that the histological mechanisms of different histological types of lung cancer may be different, and the expression status of P53 protein may also be an important parameter for estimating the prognosis of lung cancer.