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核因子κB(NF-κB)是一类能特异性地识别结合DNA的Rel类蛋白质二聚体转录因子。在静息细胞中,NF-κB与抑制性蛋白IκBs结合形成复合物,并被滞留于细胞质中而处于非活化状态;当细胞受到各种胞内外刺激时,IκBs被迅速地降解,NF-κB得以释放并进入细胞核,从而发挥其转录调节功能。NF-κB通过调控众多靶基因的转录表达而在免疫、炎症反应、细胞增殖与凋亡及肿瘤发生等许多生理学过程中发挥重要作用。4′,5,7-三羟基异黄酮(genistein)是大豆异黄酮(soybeanisoflavones)的成分之一,是大豆中一类重要非营养素成分,近年来研究显示其具有显著的防治癌症效果。
Nuclear factor kappa B (NF-κB) is a class of Rel protein dimeric transcription factors that specifically recognize bound DNA. In resting cells, NF-κB binds to the inhibitory protein IκBs to form a complex and is retained in the cytoplasm and remains inactive; IκBs are rapidly degraded when cells are stimulated by various intracellular and extracellular agents. NF-κB It is released and enters the nucleus, thus exerting its transcriptional regulatory function. NF-κB plays an important role in many physiological processes such as immunity, inflammatory response, cell proliferation and apoptosis, and tumorigenesis by regulating the transcriptional expression of many target genes. 4’,5,7-Genistein is one of the components of soybean isoflavones and an important non-nutrient component in soybean. Recent studies have shown that it has significant anti-cancer effects.