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目的 对比观察银杏叶提取物 (杏丁注射液 )与复方丹参注射液对急性脑梗死患者可溶性细胞间粘附分子 1(sICAM 1)的影响。方法 4 3例急性脑梗死患者随机分为实验组 (n =2 2 ,每日静脉滴注杏丁2 0ml,连续 14d)和对照组 (n =2 1,每日静脉滴注复方丹参注射液 2 5 0ml,连续 14d) ,动态监测治疗前后血液中sICAM 1的水平变化。结果 两组sICAM 1治疗前无显著性差异 (P >0 .0 5 ) ,治疗后第 7d ,14d实验组明显低于对照组 (P <0 .0 5 ) ;且两组患者治疗后均低于治疗前 (P <0 .0 5或P <0 .0 1)。结论 银杏叶提取物 (杏丁注射液 )在降低急性脑梗死患者血液sICAM 1的水平方面明显优于复方丹参注射液。
Objective To compare the effects of Ginkgo biloba extract (Xingding Injection) and compound Salvia Miltiorrhiza on the expression of sICAM 1 in patients with acute cerebral infarction. Methods A total of 3 acute cerebral infarction patients were randomly divided into experimental group (n = 22, daily intravenous infusion of apricot 20ml, continuous 14d) and control group (n = 21, daily intravenous infusion of compound Danshen injection 250 ml for 14 consecutive days). The levels of sICAM 1 in the blood were monitored dynamically before and after treatment. Results There was no significant difference between the two groups before sICAM 1 treatment (P> 0.05). After 7 and 14 days of treatment, the experimental group was significantly lower than the control group (P <0. 05) Before treatment (P <0.05 or P <0.01). Conclusion Ginkgo biloba extract (Xingding injection) is significantly better than compound Salvia miltiorrhiza in reducing blood levels of sICAM 1 in patients with acute cerebral infarction.