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目的研究穿心莲内酯脂质体气雾剂其药效学。方法通过二甲苯对小鼠致炎实验和小鼠热板法实验初步探讨穿心莲内酯脂质体气雾剂的抗炎与镇痛作用。结果穿心莲内酯脂质体气雾剂剂量越大,小鼠肿胀程度越低;随着剂量增加,小鼠疼痛阈值增加,差异均有统计学意义(P<0.05)。结论穿心莲内酯脂质体气雾剂具有良好的抗炎与镇痛作用。
Objective To study the pharmacodynamics of andrographolide liposomal aerosol. Methods The anti-inflammatory and analgesic effects of andrographolide liposomal aerosol were investigated by xylene-induced inflammation in mice and hot-plate test in mice. Results The larger the volume of andrographolide liposome aerosol, the lower the degree of swelling in mice. With the increase of dose, the pain threshold of mice increased, the difference was statistically significant (P <0.05). Conclusion Andrographolide liposome aerosol has good anti-inflammatory and analgesic effects.