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研究核动力堆排放废液中常见核素60CO、59Fe、51Cr、85Sr在两种年龄大鼠体内的分布、剂量及细胞遗传效应。方法予动物一次静注或口服放射性核素,定期进行全身及器官放射性测量和染色体畸变分析。结果85Sr主要聚集于骨骼;59Fe、51Cr全身广泛分布,但以肝、骨髓、红细胞含量最高;60Co主要分布于肝、肾、肺和皮毛。85Sr、59Fe、60Co在本实验条件下都能诱发骨髓和血淋巴细胞染色体畸变。结论四种核素在动物体内分布有年龄差异,摄入同量放射性核素,幼年鼠较成年鼠受到较大的辐射剂量。
The distribution, dosages and cytogenetic effects of 60Co, 59Fe, 51Cr, 85Sr, a common nuclide in spent nuclear waste liquids, were studied. Methods A single intravenous or oral administration of radionuclides to animals, regular body and organ radioactivity measurement and chromosome aberration analysis. Results 85Sr mainly gathered in the skeleton. 59Fe and 51Cr were widely distributed throughout the body, but the contents of liver, bone marrow and erythrocytes were the highest. 60Co mainly distributed in liver, kidney, lung and fur. 85Sr, 59Fe, 60Co can induce chromosomal aberrations in bone marrow and blood lymphocytes under the experimental conditions. Conclusions The four nuclides are distributed in animals with age difference. The same amount of radionuclide is taken in the animals. The juvenile rats receive a larger radiation dose than the adult mice.