弓形虫是一种专性细胞内寄生原虫,能引起人畜共患弓形虫病,严重威胁着人类健康且对畜牧业的发展造成巨大的经济损失。研制安全有效的疫苗是防制弓形虫病的策略之一。目前,弓形虫病疫苗包括灭活疫苗、减毒活疫苗、核酸疫苗、亚单位疫苗和卡介苗。本文对弓形虫病疫苗的研究现状进行了综述。 Toxoplasma gondii is a kind of obligate intracellular parasitic protozoa, which can cause zoonosis of both human and animals. It is a serious threat to human health and causes great economic losses to the development of animal husbandry. The development of a safe and effective vaccine is one of the strategies to prevent toxoplasmosis. Currently, toxoplasmosis vaccines include inactivated vaccines, live attenuated vaccines, nucleic acid vaccines, subunit vaccines and BCG. This review summarizes the research status of toxoplasmosis vaccine.