论文部分内容阅读
目的:制备槲皮素固体脂质纳米粒并对其理化性质进行考察。方法:采用乳化蒸发-低温固化法制备槲皮素固体脂质纳米粒,以正交设计优化处方和制备工艺,超滤法测定包封率,透射电子显微镜对其粒子形态进行观察,并使用激光粒度分析仪测定其粒径和Zeta电位。结果:经处方优化制备的固体脂质纳米粒平均粒径为(124.2±0.371)nm,Zeta电位为(-22.3±0.315)mV,粒子形态均匀,无粘连,平均包封率为(89.3±1.209)%。结论:制备槲皮素固体脂质纳米粒的工艺简便可行,包封率较高且纳米粒质量优良。
Objective: To prepare quercetin solid lipid nanoparticles and investigate its physico-chemical properties. METHODS: Quercetin solid lipid nanoparticles were prepared by emulsion evaporation-low temperature curing method. The orthogonal design was used to optimize the formulation and preparation process. The entrapment efficiency was determined by ultrafiltration. The particle morphology was observed by transmission electron microscopy. Particle size analyzer to determine its size and Zeta potential. RESULTS: The average particle size of the prepared solid lipid nanoparticles was (124.2 ± 0.371) nm with a Zeta potential of (-22.3 ± 0.315) mV. The average particle size was 89.3 ± 1.209 )%. Conclusion: The preparation of quercetin solid lipid nanoparticles is simple and feasible, the entrapment efficiency is high and the quality of nanoparticles is good.