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丹那唑的作用方式尚未定论,除对下丘脑—垂体水平的中枢作用外,还对卵巢类固醇生成有直接作用。培养人粒层细胞类固醇生成是以剂量依赖方式受丹那唑抑制,即使在最低剂量(100ng/ml)也有显著抑制。外周血中丹那唑浓度顺序为200～600ng/ml,在剂量为400mg/ml 后呈平稳状态。在人类组织或体液中,除血清以外,用于常规治疗子宫内膜异位症剂量的丹那唑的浓度不清。本文目的
The mode of action of Danazol is not yet conclusive, in addition to the central role of the hypothalamic-pituitary level, but also a direct role in ovarian steroidogenesis. Cultured Human Granulocytes Cell steroidogenesis is inhibited by Danazol in a dose-dependent manner, with significant inhibition even at the lowest dose (100 ng / ml). The concentration of danazol in peripheral blood was 200 ~ 600ng / ml, which showed a steady state at a dose of 400mg / ml. In human tissues or bodily fluids, the concentration of Danazol used for routine treatment of endometriosis is unclear, in addition to serum. The purpose of this article