用氚标记物研究了米酵菌酸在大鼠体内的吸收、分布与排出。结果表明,~3H-米酵菌酸经大鼠胃肠道吸收很快,灌胃后15min血浆及主要组织的放射比活性已达高峰,以肝脏为最高。24h内从尿粪排泄的放射性总量为灌胃剂量的70％。胆汁也是一条重要排泄途径,24小时内放射性总排泄量为34％。代谢物从胆汁排泄进入肠道后重新吸入肝,形成肠肝循环,使肝脏反复受到损害。 The absorption, distribution and excretion of uricase in rats were studied by tritium labeling. The results showed that ~ 3H-amylase was rapidly absorbed in the gastrointestinal tract of rats, and the radio-specific activity of plasma and major tissues reached its peak at 15 min after intragastric administration, with the highest in the liver. The total amount of radioactivity excreted from urine excrement within 24 hours was 70% of the intragastric dose. Bile is also an important excretion route, with a total radioactive excretion of 34% within 24 hours. Metabolites excreted from the bile into the intestine and re-inhalation of the liver, enterohepatic circulation, repeated damage to the liver.