报告1例混合痣并化生性骨化患者，女性，52岁，面部出现2个色痣30余年，伴瘙痒半年。检查：眉间右侧及左鼻唇沟部分别见一2．46mm×3．02mm及3．94mm×4．86mm黑褐色丘疹。组织病理示左鼻唇沟部皮损为皮内痣；而眉间部皮损为混合痣并化生性骨化，在真皮下部和皮下组织上部见3处境界清楚的骨化区，其内有哈弗逊管。对皮肤骨化的分类及病因进行了讨论。 Report of 1 case of mixed nevus and ossifying patients, female, 52 years old, facial 2 mole more than 30 years, with itching for six months. Check: the right eyebrow and the left nasolabial part respectively see a 2.46mm × 3.02mm and 3.94mm × 4.86mm dark brown papules. Histopathology showed that the left nasolabial fold lesions were intradermal nevus; and interbridement lesions were mixed nevus and metaplastic ossification, the lower dermis and the upper part of the subcutaneous tissue seen in three clear ossification of the area, which has Havison tube. The classification and etiology of ossification of the skin are discussed.