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目的探讨全身静脉化疗和髂内动脉栓塞灌注化疗对宫颈癌微淋巴管密度和血管内皮生长因子表达的影响。方法选取医院临床收治的72例宫颈癌患者和72例健康人群进行比较研究。结果宫颈癌患者的VEGF-A、C、D等3项指标水平均明显高于健康人群,且差异有统计学意义(P<0.05)。给予患者全身静脉化疗后VEGF-A和VEGF-C治疗前、后比较差异无统计学意义(P>0.05),患者的VEGF-D水平显著降低且治疗前、后比较差异有统计学意义(P<0.05);给予患者髂内动脉栓塞灌注化疗后VEGF-A治疗前、后比较差异无统计学意义(P>0.05),患者的VEGF-C和-D水平显著降低且治疗前、后比较差异有统计学意义(P<0.05);宫颈癌患者的LMVD值明显高于健康人群,差异有统计学意义(P<0.05);给予患者髂内动脉栓塞灌注化疗后,研究组和对照组患者的LMVD值均明显降低,研究组低于对照组,且差异均有统计学意义(P<0.05)。结论宫颈癌患者的宫颈癌微淋巴管密度和血管内皮生长因子表达水平会升高,髂内动脉栓塞灌注化疗方式的临床治疗效果具有显著的比较优势。
Objective To investigate the effects of systemic intravenous chemotherapy and internal iliac artery embolization chemotherapy on the expression of lymphatic vessel density and vascular endothelial growth factor in cervical cancer. Methods Seventy-two patients with cervical cancer and 72 healthy people admitted to hospital were selected for comparative study. Results The levels of VEGF-A, C and D in cervical cancer patients were significantly higher than those in healthy people (P <0.05). There was no significant difference between before and after treatment of VEGF-A and VEGF-C in patients after intravenous chemotherapy (P> 0.05), and the level of VEGF-D was significantly decreased in patients before and after treatment (P <0.05). There was no significant difference in the levels of VEGF-C and -D between the two groups before and after VEGF-A treatment (P> 0.05) (P <0.05). The LMVD of patients with cervical cancer was significantly higher than that of healthy people (P <0.05). After the patients were treated with internal iliac artery embolization and chemotherapy, the LMVD of patients in study group and control group LMVD values were significantly lower in the study group than in the control group, and the differences were statistically significant (P <0.05). Conclusion The expression of lymphatic vessel density and vascular endothelial growth factor in cervical cancer patients will increase, and the clinical effect of internal iliac artery embolization chemotherapy has significant comparative advantage.