缺氧诱导因子-2α(HIF-2α)是一种在缺氧条件下广泛存在于哺乳动物和人体内的氧敏感性转录因子,通过调节缺氧诱导基因表达参与组织细胞对低氧的适应性应答,其表达是机体适应低氧的关键环节和起始步骤。近年研究发现HIF-2α可能与脂代谢过程有密切联系。本文就HIF-2α对脂肪酸代谢和胆固醇代谢的调节作用作一综述。 Hypoxia-inducible factor-2alpha (HIF-2alpha) is an oxygen sensitive transcription factor widely present in mammals and humans under hypoxia and is involved in the adaptation of tissue cells to hypoxia by regulating hypoxia-induced gene expression Response, the expression of the body to adapt to the key part of hypoxia and the initial step. Recent studies have found that HIF-2α may be closely linked with lipid metabolism. This review summarizes the regulatory effect of HIF-2α on fatty acid metabolism and cholesterol metabolism.