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以聚乳酸为壁材，利用超声乳化同W1／O／W2复乳化方法相结合的方法，设计合成囊壁载有油溶性Fe3 O4纳米粒子的磁性中空聚乳酸微囊。扫描电子显微镜分析（ SEM）显示微囊外表面光滑，平均直径为1μm；透射电子显微镜（ TEM）分析显示微囊中空结构明显，Fe3 O4纳米粒子集中分布于囊壁结构。采用热重分析法（ TGA）测定磁性微囊中Fe3 O4质量分数高达12％。制得的磁性微囊具有较好的复溶性，在水溶液中能稳定分散，并具有较好的磁响应性，可望成为一种有效的磁靶向给药载体材料。“,”The biodegradable magnetic poly lactic acid ( PLA) microcapsules with Fe3 O4 nanoparticles in the wall were designed and prepared based on the combination of ultrasonic emulsification technique and double emulsion?solvent evap?oration method. Fe3 O4 nanoparticles were prepared by coprecipitation method, and coated with undecylenic acid and oleic acid to improve its stability in dichloromethane. The structure and morphology of the magnetic PLA microcapsules were analyzed by scanning electron microcopy ( SEM ) and transmission electron microscopy ( TEM ) . Moreover, the thermal properties of the magnetic PLA microcapsules were measured by thermogravimetric analysis ( TGA) . As demon?strated by experimental results, the diameter of the uniform magnetic microcapsules was about 1 μm, and the magnetic PLA microcapsules could be easily separated from aqueous solution by an external magnetic field.