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RU_(486)是一种孕酮拮抗剂,妇女或雌猴黄体中晚期用RU_(486)能诱导月经,RU_(486)与子宫内膜中孕酮受体的亲和力比孕酮(P)约大10倍。在黄体期用RU_(486)后往往有2次月经出血——RU_(486)治疗期间出血和残留黄体自然退化时的出血。作者企图阐明此2次出血原因是否第1次由于子宫内膜表层脱落,第2次由于RU_(486)对宫底、宫体和峡部的宫内膜作用不均匀,设计了以下研究:实验采用于周期第18天用腹腔镜检查发现有新的黄体形成,从而证实为正常排卵周期的7只雌猴,于腹腔镜检查当天从股静脉取血用放射免疫法测定P水平,证实血P水平为正常黄体早期(2.2±1.47ng/ml)。将猴分成3组:Ⅰ组3只于周期第21～24天肌注RU_(486)5mg/kg/日(溶于90%乙醇中);Ⅱ组2只除与I
RU_ (486) is a progesterone antagonist, RU_ (486) can induce menstruation in the late stage of female or rhesus monkey corpus luteum, and the affinity of RU_ (486) with progesterone receptor in endometrium is higher than that of progesterone Big 10 times. There are often 2 menstrual bleeding after RU_ (486) in the luteal phase - Bleeding during RU_ (486) treatment and bleeding when the residual luteal tract naturally degenerates. The authors attempted to elucidate whether the second cause of bleeding was due to the first exfoliation of the endometrium and the second due to the uneven endometrial effects of RU_ (486) on the fundus, uterus and isthmus. The following studies were designed: On the 18th day of the cycle, a new corpus luteum formation was found by laparoscopy, which confirmed that there were 7 female monkeys with normal ovulation cycle. Blood samples were taken from the femoral vein on the day of laparoscopy and the level of P was determined by radioimmunoassay. The normal early luteal phase (2.2 ± 1.47ng / ml). The monkeys were divided into 3 groups: Group Ⅰ was intramuscularly injected RU 486 5 mg / kg / day (dissolved in 90% ethanol) on days 21-24 of Group Ⅰ;