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小鼠乳腺肿瘤病毒(mouse mammary tumor virus,MMTV)自首次研究发现与人类乳腺癌有关联后,研究人员进行一系列研究以验证MMTV作为与乳腺癌相关的人类病原体的假设,主要从基因水平、免疫学反应、流行病学等方面研究,很多研究结果支持MMTV与人类乳腺癌存在相关,特别是在基因方面,如发现了许多MMTV整合到人DNA的位点,乳腺癌组织存在MMTV样病毒的序列等,但仍未获得具有较强说服力的直接证据,而且也有不少的研究结果是相反,因此,还要不断研究才能提供更实质证据验证MMTV在乳腺癌存在与否、及其潜在的作用。
Since the first study found that mouse mammary tumor virus (MMTV) was associated with human breast cancer, the researchers conducted a series of studies to test the hypothesis that MMTV acts as a human pathogen associated with breast cancer, primarily at the genetic level, Immunology, epidemiology and other aspects of research, many studies support the existence of MMTV and human breast cancer, especially in the gene, such as the discovery of many MMTV integration into human DNA sites, breast cancer tissue exists MMTV-like virus Sequence, but there is still no direct evidence of strong persuasion, and many of the results are the opposite, therefore, we must continue to study in order to provide more substantive evidence to verify the presence of MMTV in breast cancer, and its potential effect.