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目的对78例非神经系统恶性肿瘤致神经系统损害患者进行临床回顾性分析,以期为临床诊疗积累资料。方法收集2010年3月至2013年5月就诊的非神经系统恶性肿瘤致神经系统损害患者78例,并对其进行回顾性分析。结果本研究共纳入患者78例,其中男性48例,女性30例,男女比例1.6:1。年龄以50~59岁间为最多,占41.0%,不同性别间年龄构成差异无统计学意义(2=2.685,P=0.069);患者同时伴高血压者18例(23.1%),糖尿病者15例(19.2%),起病形式多为亚急性或慢性,共44例(56.4%);首诊误诊例数23例(29.5%),平均首诊误诊时间为(9.7±4.1)d,随着年龄增加,首诊误诊率和误诊天数降低,差异均有统计学意义(均P<0.05);引起神经系统症状的恶性肿瘤中,以肺癌最为多见,占59.0%,其次为肝癌,占10.3%,再次为乳腺癌,占7.7%;78例患者中,64例(82.1%)以神经系统症状为首发症状。结论非神经系统恶性肿瘤所致神经系统损害具有规律性,临床应尽早进行诊断和治疗。
Objective To retrospectively analyze 78 patients with neurological damage caused by non-neurological malignancies in order to accumulate data for clinical diagnosis and treatment. Methods 78 patients with neurological damage caused by non-neurological malignancies treated from March 2010 to May 2013 were retrospectively analyzed. Results A total of 78 patients were enrolled in this study, including 48 males and 30 females, with a male to female ratio of 1.6: 1. The age was from 50 to 59 years old, accounting for 41.0%. There was no significant difference in age between two sexes (2 = 2.685, P = 0.069). There were 18 patients (23.1%) with hypertension and diabetes Among the 15 cases (19.2%), most of them were subacute or chronic in 44 cases (56.4%). The first misdiagnosed cases were 23 cases (29.5%), the average first misdiagnosed time was (9.7 ± 4.1) With the increase of age, the first misdiagnosis rate and the number of misdiagnosis days decreased, the difference was statistically significant (all P <0.05); among the malignant tumors causing neurological symptoms, lung cancer was the most common, accounting for 59.0%, followed by liver cancer, Accounted for 10.3%, again for breast cancer, accounting for 7.7%; 78 patients, 64 cases (82.1%) with neurological symptoms as the first symptom. Conclusion Nervous system damage caused by non-nervous system malignancies has regularity. Clinical diagnosis and treatment should be done as soon as possible.