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目的：探讨肾小球滤过率的改变对早期确诊糖尿病肾病的临床意义。方法：对59例糖尿病病人用99mTc－DTPA肾动态显像测定肾小球滤过率（GFR），同时测血β2微球蛋白、尿素氮、肌酐，尿微量白蛋白排泄率，并进行比较。结果：出现微量蛋白尿时，GFR已有明显下降。结论：GFR测定能早期发现糖尿病肾病及其损害程度。
Objective: To investigate the clinical significance of the change of glomerular filtration rate in the early diagnosis of diabetic nephropathy. Methods: The glomerular filtration rate (GFR) was measured by 99mTc-DTPA renal dynamic imaging in 59 patients with diabetes mellitus. Meanwhile, the β2 microglobulin, urea nitrogen, creatinine and urinary albumin excretion rate were measured and compared. Results: When microalbuminuria appeared, GFR had obviously decreased. Conclusion: GFR can detect early diabetic nephropathy and its damage.