对结构式二酮衍生物选择性酶促还原(Ⅰ)(其中包括无环结构,一个或多个杂原子)包括在还原型辅酶NADH或NADPH为的存在下,氧化还原酶/脱氢酶减少二酮衍生物,其中二酮衍生物的反应开始时使用浓度≥10g/L;和连续再生氧化辅酶NAD和NADP还原酶/脱氢酶的形成。R1氢或1~4个碳的烷基;R2:氢,1~8个碳的烷基或羟基保护基团,如酯;R3:氢、甲基或卤化物;而A:苯环或六碳环上有 The selective enzymatic reduction (I) (including acyclic structures, one or more heteroatoms) to the structural diketone derivatives includes the reduction of the oxidoreductase / dehydrogenase enzyme in the presence of reduced coenzyme NADH or NADPH Ketone derivatives wherein the diketone derivative is used at a concentration of> 10 g / L at the beginning of the reaction; and the formation of a continuous regenerative oxidative coenzyme NAD and NADP reductase / dehydrogenase. R1 hydrogen or alkyl of 1 to 4 carbon atoms; R2 hydrogen, an alkyl or hydroxyl protecting group of 1 to 8 carbons, such as an ester; R3 hydrogen, methyl or halide; and A: There is carbon ring