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用放免法测定110例心力衰竭(CHF)患者及35例正常人的肾素(PRA)、血管紧张素(A_Ⅰ)、醛固酮(ALD)、心钠素(ANF)、有效肾血流量(ERPF),部分人测定尿钠/24h。结果显示CHF时ERPF、尿钠/24h明显下降,PRA、A_Ⅰ、ALD和ANF明显增高,并随心衰加重改变愈著,尤以肺心病最著。CHF时PRA、A_Ⅰ、ALD呈正相关;PRA与ERPF负相关,与尿纳/24h不相关;ERPF、尿钠/24h与ALD不相关,与A_Ⅰ负相关;ANF与ERPF负相关,与尿钠/24h、PRA、A_Ⅰ和ALD不相关。 提示CHF时上述神经体液因素失去正常规律
(PRA), angiotensin (A_Ⅰ), aldosterone (ALD), atrial natriuretic peptide (ANF) and effective renal blood flow (ERPF) were measured in 110 patients with heart failure and 35 normal subjects by radioimmunoassay. Some people measured urine sodium / 24h. The results showed that ERPF, urinary sodium / 24h were significantly decreased, PRA, A_Ⅰ, ALD and ANF were significantly increased in CHF patients. PRA, A_I and ALD were positively correlated; PRA was negatively correlated with ERPF, not related with urinary sodium / 24h; ERPF, urinary sodium / 24h was not related with ALD, but negative with A_I; ANF was negatively correlated with ERPF, 24h, PRA, A_I and ALD are not related. Hint CHF when the above neurohumoral factors lost the normal law