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研究186Re(Sn)-HEDP药盒中冻干品的制备,以及冻干品各成份(Vc,HEDP和SnCl2·2H2O)的有效含量的测定,以实现质量控制。同时,研究了反应温度和反应时间对药盒标记的影响以及186Re(Sn)-HEDP在动物体内的分布情况。初步的动物实验结果表明:186Re(Sn)-HEDP骨组织吸收高,在血液中的清除速度快。
The preparation of lyophilized product in 186 Re (Sn) -HEDP kit and the determination of the effective content of each component (Vc, HEDP and SnCl2 · 2H2O) of lyophilized product were studied in order to achieve quality control. At the same time, the effects of reaction temperature and reaction time on the labeling of the kit and the distribution of 186Re (Sn) -HEDP in animals were studied. Preliminary animal experiments show that: 186Re (Sn) -HEDP bone tissue absorb high in the blood clear faster.