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目的 探讨血浆合肽素在慢性阻塞性肺疾病(简称慢阻肺)急性加重期中的临床意义.方法 选取2013年10月至2015年11月在我院呼吸科收治的慢阻肺急性加重患者90例作为慢阻肺急性加重组,同期查体健康者40例作为对照组.采用酶联免疫吸附法检测血浆合肽素水平.比较慢阻肺急性加重患者治疗前后合肽素、白细胞计数(WBC)、C反应蛋白(CRP)的变化.分析慢阻肺急性加重组血浆合肽素水平与病情严重程度的相关性.结果 慢阻肺急性加重组血浆合肽素明显高于对照组[(16.4±5.2) pmol/L vs.(5.7±2.8)pmol/L,P＜0.05],且随病情加重逐渐升高.慢阻肺急性加重患者治疗前、后血浆合肽素水平与血浆CRP、外周血白细胞总数呈正相关(P＜0.05).结论 血浆合肽素水平与慢阻肺急性加重病情程度相关,合肽素水平可作为慢阻肺急性加重患者病情严重程度的一种观察指标.“,”Objective To investigate the clinical value of plasma copeptin in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods Ninety patients with AECOPD admitted between October 2013 and November 2015 were recruited as an AECOPD group,and 40 healthy subjects underwent physical examination simultaneously were recruited as a control group.According to patient history and severity,the AECOPD patients were divided into 3 groups:grade I group (25 cases),grade Ⅱ group (45 cases) and grade Ⅲ group (20 cases).Plasma copeptin level was measured by enzyme-linked immunosorbent assay (ELISA).The changes of copeptin,the total counts of white blood cells (WBC),and C-reactive protein (CRP) of the AECOPD patients were compared before and after treatment.Then the correlations between plasma levels of copeptin and severity of AECOPD were evaluated.Results The plasma level ofcopeptin in the AECOPD group was higher than that in the control group [(16.4±5.2) pmol/L vs.(5.7±2.8) pmol/L,P＜0.05),and gradually increased with the severity of AECOPD.For the AECOPD patients both before and after treatment,the copeptin concentrations were positive correlated with the plasma CRP concentrations and the total counts of WBC in blood (both P＜0.05).Conclusions The plasma levels of copeptin gradually increase with the severity of AECOPD.The changes of plasma copeptin may be as an indicator for the severity of AECOPD.