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目的:分析前列地尔联合培哚普利治疗糖尿病肾病蛋白尿的疗效,探讨其临床适用性。方法:回顾性分析从2013年7月~2016年7月于我院就诊的94例糖尿病肾病患者,简单随机分为观察组47例和对照组47例,对照组患者给予培哚普利治疗,观察组在此基础上联合前列地尔治疗。观察两组患者血糖控制情况,两组患者蛋白尿的治疗疗效,治疗前后24h尿蛋白定量,血肌酐和尿素氮等肾功指标的变化情况和用药期间的不良反应情况。结果:两组患者治疗前空腹血糖(FPG)、2h餐后血糖(2h-PG)及糖化血红蛋白(HbA1c)指标比较,差异无统计学意义;治疗后两组患者的FPG、2h-PG和Hb A1c均降低,差异有统计学意义,但两组间比较,差异无统计学意义,观察组患者治疗后的总有效率为97.87%,对照组患者的总有效率为87.23%,两组患者总有效率比较,差异有统计学意义,治疗前两组患者的24h尿蛋白量,血肌酐和尿素氮之间比较无明显差异,两组患者治疗后均降低,且观察组患者治疗后24h尿蛋白量,血肌酐和尿素氮均低于对照组,两组患者治疗期间均未出现严重不良反应情况。结论:前列地尔联合培哚普利治疗糖尿病肾病蛋白尿疗效确切,可以有效改善肾功能,适合临床应用。
Objective: To analyze the curative effect of alprostadil combined with alprostadil on diabetic nephropathy proteinuria and its clinical applicability. Methods: A retrospective analysis of 94 patients with diabetic nephropathy treated in our hospital from July 2013 to July 2016 were randomly divided into observation group (n = 47) and control group (n = 47). Patients in the control group were treated with perindopril, The observation group based on this combination of alprostadil treatment. To observe the two groups of patients with glycemic control, two groups of patients with albuminuria treatment efficacy, 24h proteinuria before and after treatment, serum creatinine and urea nitrogen and other indicators of kidney function changes and adverse reactions during the medication. Results: There was no significant difference in fasting blood glucose (FPG), 2h-PG and HbA1c before treatment, FPG, 2h-PG and Hb A1c were decreased, the difference was statistically significant, but there was no significant difference between the two groups, the total effective rate of the observation group after treatment was 97.87%, the total effective rate of the control group was 87.23%, the total two groups of patients Effective comparison, the difference was statistically significant, the first two groups of patients before treatment 24h urinary protein, serum creatinine and urea nitrogen was no significant difference between the two groups were reduced after treatment, and the observation group patients 24h urinary protein Volume, serum creatinine and urea nitrogen were lower than the control group, no serious adverse reactions during the treatment of both groups. Conclusion: The combination of alprostadil and perindopril in the treatment of diabetic nephropathy proteinuria is effective, which can effectively improve renal function and is suitable for clinical application.