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目的分析研究对接受无创正压通气治疗的重度急性有机氟中毒患者实施呼吸功能训练对其肺功能的影响。方法62例重度急性有机氟中毒患者,随机分为观察组与对照组,各31例。两组患者均进行无创正压通气治疗,对照组仅进行日常锻炼,观察组进行缩唇-腹式呼吸及人工阻力呼吸训练,对比观察两组患者治疗效果、肺通气功能变化情况及治疗前后血清α-AT1、SP-D、NE、TGF-β1和生活质量变化情况。结果观察组治疗总有效率为93.55%,高于对照组的74.19%,且FEV1、FEV1与FVC比值、VC、DLco及MVV水平均明显优于对照组,差异有统计学意义(P<0.05);治疗前两组血清中α-AT1、SP-D、NE、TGF-β1水平及生活质量评分比较,差异无统计学意义(P>0.05);治疗后,观察组各项指标及生活质量评分均明显优于对照组,差异有统计学意义(P<0.05)。结论重度急性有机氟中毒患者在无创正压通气治疗基础上采用呼吸功能训练,可有效改善血清各项指标,稀释体内毒性,恢复患者肺部功能,对提高其治疗效果和生活质量具有重要意义,值得推广运用。
Objective To study the effect of respiratory function training on pulmonary function in patients with severe acute fluorosis who received noninvasive positive pressure ventilation. Methods Sixty-two patients with severe acute fluorosis were randomly divided into observation group and control group, with 31 cases in each group. Two groups of patients were treated with noninvasive positive pressure ventilation, the control group only for daily exercise, the observation group were reduced lip - abdominal respiration and artificial resistance breathing training, compared the two groups of patients with therapeutic effect, changes in pulmonary ventilation function and serum before and after treatment α-AT1, SP-D, NE, TGF-β1 and quality of life. Results The total effective rate of the observation group was 93.55%, higher than that of the control group (74.19%). The FEV1, FEV1 and FVC ratio, VC, DLco and MVV levels were significantly better than the control group, the difference was statistically significant (P 0.05) ; The serum levels of α-AT1, SP-D, NE, TGF-β1 in the two groups before treatment and the quality of life scores were not significantly different (P> 0.05); After treatment, the indicators of the observation group and the quality of life score Were significantly better than the control group, the difference was statistically significant (P <0.05). Conclusion The patients with severe acute fluorosis had respiratory function training based on non-invasive positive pressure ventilation, which can effectively improve the serum indexes, dilute the toxicity in vivo and restore the lung function of patients, which is of great significance to improve the therapeutic effect and quality of life. Worth to promote the use.