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目的 研究血管内皮生长因子 (VEGF)表达与人脑转移瘤瘤周脑水肿 (PTBE)的关系。方法 采用免疫组织化学SP法检测 2 6例人脑转移瘤的VEGF表达 ;术前行MRI检查 ,T2 WI测定PTBE大小 ,并与瘤体体积相比较计算脑水肿指数 (EI)。结果 2 6例脑转移瘤均表达强度不等的VEGF ,VEGF平均吸光度值 (A值 )范围为 0 .10 2～ 0 .196 ( 0 .14 7± 0 .0 2 3) ;且在MRI上都表现有不同程度PTBE(水肿指数为EI =4.13± 0 .41)。VEGF表达水平与EI呈正相关 (r=0 .76 0 ,Ρ <0 .0 5 )。结论 VEGF可能参与脑转移瘤PTBE发生 ;VEGF表达与转移瘤PTBE的相关性 ,对临床治疗脑水肿具有重要参考价值。
Objective To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and brain metastases of human brain tumor (PTBE). Methods The expression of VEGF in 26 cases of human brain metastases was detected by immunohistochemical SP method. The size of PTBE was measured by MRI before T2WI and the cerebral edema index (EI) was calculated compared with the tumor volume. Results The average values of VEGF and VEGF in 26 cases of brain metastases were all from 0 102 to 0 196 (0.14 7 ± 0. 02 23). On MRI All showed varying degrees of PTBE (edema index was EI = 4.13 ± 0.41). The expression of VEGF was positively correlated with EI (r = 0.76 0, P <0.05). Conclusions VEGF may be involved in the occurrence of PTBE in brain metastases. The correlation between VEGF expression and metastatic tumor PTBE may be an important reference for clinical treatment of cerebral edema.