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目的:研究模拟深埋条件下缺氧复合缺水缺食时动脉血气参数的变化规律和特点。方法:应用Wistar大鼠80只(雌雄各半)和雄性比格犬6只,前者随机分为单纯缺氧组(氧含量10%)、缺食缺水组、缺氧缺食缺水组和正常对照组,后者仅为缺氧缺水缺食,于致伤后第1天、第3天、第7天、第9天、第11天、第12天、第14天动态和对比性检测动脉血气和多种离子的浓度。结果:1.缺氧缺食缺水组比格犬于11.9～14.9天全部死亡,其PaO_2和PaCO_2值于第1天即均显著下降(P<0.01),持续至死亡,分别仅为伤前的48.5%～55.5%和56.5%～66.4%,红细胞比容(Hct)比值同样于第1天即显著增高,最高达到75.0%;Na~+和Cl~-浓度分别在第5天和第1天后即明显增高,K~+度仅略呈升高趋势;2.大鼠动脉血气和多种离子的浓度变化与比格犬组基本呈类似规律,其中动脉血气变化于雄性和雌性组间差异不显著,而血Na~+、Cl~-和K~+浓度则以雄性较雌性显著。结论:深埋条件下缺氧复合缺水缺食时发生动脉血PaO_2和PaCO_2值下降,血清离子浓度紊乱和血液浓缩,具有快速性、持续性和进行性特点。
Objective: To study the changes and characteristics of arterial blood gas parameters under hypoxia combined with water deficit under simulated deep-sea conditions. Methods: 80 Wistar rats (half male and half female) and 6 male beagle dogs were randomly divided into three groups: the hypoxia group (oxygen content 10%), the lack of water group, the hypoxia group Normal control group, the latter only lack of water and lack of food, on the first day, the third day, the seventh day, the ninth day, the eleventh day, the twelfth day, the fourteenth day dynamic and contrast Detect arterial blood gas and various ion concentrations. In the hypoxia-deficient group, Beagle dogs all died from 11.9 to 14.9 days. The values of PaO_2 and PaCO_2 decreased significantly on the first day (P <0.01), and continued to death, which were only pre-injury 48.5% -55.5% and 56.5% -66.4% respectively. The ratio of hematocrit (Hct) also increased significantly at day 1, up to 75.0%. The concentrations of Na ~ + and Cl ~ The level of K ~ + increased only slightly after 2 days; 2. The changes of arterial blood gas and various ions in rats were basically similar to those in beagle dogs, and the changes of arterial blood gas between the male and female groups Not significant, while blood Na ~ +, Cl ~ - and K ~ + concentrations were more pronounced in males than females. CONCLUSION: PaO2 and PaCO_2 in arterial blood are decreased during hypoxia combined with lack of water under deep-buried conditions. Serum ion concentration is disturbed and blood is concentrated, which has the characteristics of rapid, persistent and progressive.