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本文分析４８例儿童系膜ＩｇＭ肾病（ＩｇＭＮ）的临床表现与病理改变，占同期原发性肾小球疾病肾活检总数的２１．５％。临床表现为肾病综合征３７例（７７．１％），单纯性蛋白尿８例（１６．７％），迁延性肾炎３例（６．２％）。病理类型：局灶性系膜增殖（ＭｓＰＧＮ）１６例（３３．３％），弥漫性系膜增殖２９例（６０．４％），微小病变（ＭＣＮ）２例（４．２％），轻微损害（ｍｉｎｏｒｌｅｓｉｏｎ）１例（２．１％）。有１２例（２５％）系膜区见到电子致密物沉积。４８例均见到ＩｇＭ呈颗粒状沉积于系膜区及血管拌（１１例）。对强的松治疗多数反应较差，且易反复发作。作者随访３５例，多数预后良好，仅３例（８．６％）患儿有轻度肾功能减退。
In this paper, 48 cases of children with mesangial IgM nephropathy (IgMN) clinical manifestations and pathological changes, accounting for the same period the primary glomerular disease, the total number of 21.5% of renal biopsies. Clinical manifestations of nephrotic syndrome in 37 cases (77.1%), simple proteinuria in 8 cases (16.7%), 3 cases of persistent nephritis (6.2%). Pathological types: 16 cases (33.3%) of focal mesangial proliferation (MsPGN), 29 cases (60.4%) of diffuse mesangial proliferation, 2 cases of minimal change (MCN) One case (2.1%) of minor lesion. In 12 cases (25%) mesangial area to see the deposition of electron dense material. 48 cases were seen IgM deposition in the mesangial area and vascular mixed (11 cases). Most of the treatment of prednisone poor response, and easy to recurrent. The authors followed up 35 cases, most of the good prognosis, only 3 cases (8.6%) had mild renal dysfunction.