论文部分内容阅读
Objective:To illustrate the clinical features and investigate the indicators associated with a fatal outcome in adult patients with severePlasmodium falciparum malaria admitted to the Hospital for Tropical Diseases, Bangkok, Thailand.Methods: We studied202adult malaria patients admitted to the Intensive Care Unit. A total of43 clinical variables were identified by univariate and logistic regression analyses, to eliminate confounding factors.Results: Regarding the statistical methods, only 6variables-jaundice, cerebral malaria, metabolic acidosis, body mass index, initial respiratory rate, and white blood cell count-were significant indicators of death, with adjusted odds ratios (95%CI)of 15.2 (2.1-32.3), 4.3 (2.3-12.6), 3.3 (2.3-5.7), 2.4 (1.9-3.5), 2.2 (1.5-2.6), and1.7 (1.2-3.1), respectively.Conclusions: Our study found that jaundice, cerebral malaria, metabolic acidosis, body mass index, initial respiratory rate and white blood cell count were indicators of fatal outcome in severe Plasmodiumfalciparum malaria. Further studies on the fatal indicators in severe malaria need to be compared with data from different geographical areas, to construct practical measures to address potentially fatal indicators in different settings.