论文部分内容阅读
目的评价成人按不同程序接种乙肝疫苗的免疫效果,为制定成人乙肝免疫策略提供支持。方法按照自愿原则选择桐乡市HBs Ag和抗-HBs均阴性16~49岁人群,分别按0-1-3、0-1-6免疫程序接种国产和进口两种10μg乙肝疫苗,全程免疫后1个月和1年定量检测抗-HBs,对釆用10μg国产乙肝疫苗A组(0-1-3程序)、B组(0-1-6程序),10μg进口乙肝疫苗C组(0-1-3程序)、D组(0-1-6程序)接种后的抗-HBs阳转率、抗-HBs几何平均滴度(GMT)水平进行评价。结果完成全程免疫并采集双份免后血样共848人,免疫1个月后抗-HBs阳转率为99.76%,A组与C组、B组与D组、A组与B组、C组与D组免后抗-HBs阳转率差异均无统计学意义(P>0.05);A组的抗-HBs GMT低于C组和B组(P<0.05),B组与D组抗-HBs GMT差异无统计学意义(P>0.05);低年龄组抗-HBs GMT比高年龄组高。免疫1年后抗-HBs阳转率为70.28%,抗-HBs阳性率和抗-HBs GMT均较免后1个月降低。结论成人采用国产10μg乙肝疫苗按0-1-6免疫程序接种的免疫效果较好。
Objective To evaluate the immunogenicity of hepatitis B vaccination among adults according to different procedures and to provide support for the development of adult hepatitis B immunization strategies. Methods According to the voluntary principle, HBs Ag and anti-HBs in Tongxiang were selected to be both 16-49-year-old negative. The vaccinated domestic and imported 10μg hepatitis B vaccines were vaccinated respectively according to 0-1-3 and 0-1-6 immunization procedures. After 1 Months and 1 year quantitative detection of anti-HBs, preclude the use of 10μg of domestic hepatitis B vaccine A group (0-1-3 program), B group (0-1-6 program), 10μg of imported hepatitis B vaccine C group (0-1 -3 program), anti-HBs positive rate after inoculation in group D (0-1-6 program) and geometric mean titer (GMT) level of anti-HBs were evaluated. Results A total of 848 blood samples were collected for immunization and double immunization. After 1 month of immunization, the anti-HBs positive rate was 99.76%. A group and C group, B group and D group, A group and B group, C group (P> 0.05). The anti-HBs GMT in group A was lower than that in group C and group B (P <0.05), but the anti-HBs positive rate in group B was not significantly different from that in group D HBs GMT was no significant difference (P> 0.05); low age group anti-HBs GMT than the high age group. After 1 year of immunization, the positive rate of anti-HBs was 70.28%, and the positive rate of anti-HBs and the anti-HBs GMT were all lower than those of 1 month after immunization. Conclusion Adult immunized with 10μg Hepatitis B vaccine according to 0-1-6 immunization program is better.