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目的观察以盖诺(长春瑞滨)为主的联合化疗方案治疗术后食管癌的疗效及安全性。方法选择食管癌术后患者联合化疗,盖诺25 mg/m2静脉滴注d1及d5,顺铂30 mg/m2静脉滴注d2至d4,5氟-脲嘧啶500 mg/m2静脉滴注4 h d1至d5,3~4周重复。结果治疗后近期疗效有效率84.4%。主要副反应为恶心、呕吐及白细胞减少,但多为Ⅰ~Ⅱ级。结论盖诺毒副作用可以耐受,盖诺联合顺铂及5氟-脲嘧啶联合化疗方案疗效显著,毒性反应能耐受,且费用低,值得推广。
Objective To observe the efficacy and safety of combined chemotherapy with greno (vinorelbine) in the treatment of postoperative esophageal cancer. Methods Patients undergoing combined esophageal cancer chemotherapy were treated with intravenous drip of dicamba 25 mg / m2 d1 and d5, cisplatin 30 mg / m2 intravenous infusion of d2 to d4,5 fluorouracil 500 mg / m2 for 4 h d1 to d5, 3 to 4 weeks repeat. The results of the treatment of 84.4% immediate effect. The main side effects of nausea, vomiting and leukopenia, but mostly Ⅰ ~ Ⅱ grade. CONCLUSION: The side effects of Gynol can be tolerated. GUNOTOXIN combined with cisplatin and 5-fluorouracil combined with chemotherapy have significant curative effect, tolerable toxicity and low cost, which is worthy of promotion.