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目的:探索皮质骨轨迹螺钉及骶骨翼螺钉内固定技术在治疗腰椎邻近节段退变疾病中的应用并评估其临床疗效。方法:分析2017年1月至2019年12月于首都医科大学附属北京朝阳医院因腰椎邻近节段退变（ASD）应用皮质骨轨迹螺钉（CBTS）和骶骨翼螺钉（SAS）内固定技术进行腰椎后路减压融合术的24例患者资料。其中男14例，女10例，年龄（67.9±8.2）岁，随访时间（2.6±0.4）年。统计手术时间、术中出血量、术后下地时间等围手术期指标。对所有患者进行至少2年的随访，比较术前及末次随访时腰痛和腿痛视觉模拟评分（VAS）和Oswestry功能障碍指数（ODI）评分，通过影像学检查判断是否发生内固定松动、假关节形成和再次邻近节段退变。结果:24例患者中近端ASD患者14例，远端腰骶部ASD患者8例，近端远端同时ASD 1例，上下融合中间节段ASD（“夹心”ASD）1例。邻近椎体骨密度（双能X线吸收测量法，T值）为-1.98±0.91，其中10例T值<-2.5。手术时间为（125±36）min，术中出血量为（85±33）ml。术后下地时间为（3.1±1.9）d，住院日为（9.0±2.6）d。术前患者腰痛VAS为（5.2±1.0）分，腿疼（6.8±1.9）分，ODI评分56.6%±12.8%。末次随访患者腰痛VAS为（1.4±0.6）分，腿疼（0.9±0.4）分，ODI评分13.8%±6.3%。末次随访患者各指标评分均较术前明显改善，差异均有统计学意义（均n P<0.01），总体临床效果满意。在末次随访中，未出现螺钉松动及假关节形成等内固定相关并发症，尚未再次出现症状性邻近节段退变。n 结论:CBTS及SAS内固定技术应用于腰椎ASD的手术治疗，具有创伤小、术后恢复快、内固定可靠且并发症少等优势，尤其对于骨量降低的老年患者是一种可靠的选择。“,”Objective:To explore the application of cortical bone trajectory screw (CBTS) and sacral alar screw (SAS) internal fixation in the treatment of lumbar adjacent segment degeneration (ASD) and evaluate its clinical effect.Methods:Data of 24 patients who were diagnosed with ASD and treated by CBTS or SAS in Beijing Chaoyang Hospital were retrospectively reviewed. There were 14 males and 10 females with a mean age of (67.9±8.2) years. The patients were followed-up for (2.6±0.4) years. Perioperative parameters including operation time, intraoperative blood loss and postoperative time on the ground were counted. All patients were followed-up for at least 2 years. Visual analogue scale (VAS) and the Oswestry disability index (ODI) were compared between pre-operation and at the last follow-up. The internal fixation-related complications, pseudarthrosis and adjacent re-degeneration were evaluated in the follow-up.Results:There were 14 proximal ASD patients, 8 distal ASD patients, 1 both ends ASD patient and 1 ASD patient in between the fusion surgeries. Bone mineral density (BMD) T score of the adjacent vertebrae was -1.98±0.91 on average. The ASD patients were re-operated with CBTS and SAS internal fixation technique. A small incision was made in the revision surgery and the original fixation was not completely cut open and removed. The mean operation time was (125±36) min, mean blood loss was (85±33) ml. The postoperative ambulation time was (3.1±1.9) days, and the hospitalization time was (9.0±2.6) days. Before the operation, the average VAS (back pain) score was 5.2±1.0, the average of VAS (leg pain) score was 6.8±1.9 and ODI was 56.6%±12.8%. VAS score was reduced to 1.4±0.6 (waist pain) and 0.9±0.4 (leg pain). ODI was improved to 13.8%±6.3%. All the difference between preoperative and the last follow-up was statically significant (all n P<0.01). No internal fixation failure, pseudarthrosis and adjacent re-degeneration were observed in the final follow-up.n Conclusion:The application of CBTS and SAS internal fixation techniques in the surgical treatment of lumbar ASD has the advantages of less trauma, faster postoperative recovery, reliable internal fixation, and fewer complications, especially in patients with low bone mineral density.