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目的探讨降钙素原及C反应蛋白在儿童感染性疾病诊断中的价值。方法分别采用半定量免疫层析法(PCT-Q)、免疫散射比浊法对196例疑似感染的住院患儿进行降钙素原及C反应蛋白的测定,按照出院诊断将资料分为细菌感染组、病毒感染组、非感染组3组,进行统计学处理。结果细菌感染组PCT阳性80例(86.02%),非感染组阳性2例(5.26%),两组比较有(P<0.001,χ2=75.15);病毒感染组PCT阳性1例(1.54%),与细菌感染组比较,差异有统计学意义(P<0.001,χ2=109.30)。细菌感染组CRP阳性27例(29.03%);非感染组CRP阳性4例(10.53%),两组比较,P=0.026<0.05(χ2=4.96),有统计学意义;病毒感染组阳性3例(4.61%),与细菌感染组比较,P<0.001(χ2=14.43),差异有统计学意义。结论PCT在临床早期判断是否存在细菌感染有重要的参考价值,在治疗过程中动态观察PCT水平,可判断疗效和预后。CRP对协助诊断儿童感染方面有一定参考价值,但与PCT组相比,其检出率和敏感度均低于PCT。
Objective To investigate the value of procalcitonin and C-reactive protein in the diagnosis of infectious diseases in children. Methods Sixty-six inpatients with suspected infection were assayed for procalcitonin and C-reactive protein using semi-quantitative immunochromatography (PCT-Q) and immunostaining turbidimetry respectively. The data were divided into bacterial infection Group, virus infection group, non-infected group 3, for statistical analysis. Results There were 80 PCT positive cases (86.02%) in bacterial infection group and 2 (5.26%) positive cases in non-infected group (P <0.001, χ2 = 75.15) Compared with the bacterial infection group, the difference was statistically significant (P <0.001, χ2 = 109.30). The positive rate of CRP in bacterial infection group was 27 cases (29.03%). The non-infected group was CRP positive in 4 cases (10.53%), P = 0.026 <0.05 (χ2 = 4.96) (4.61%), compared with the bacterial infection group, P <0.001 (χ2 = 14.43), the difference was statistically significant. Conclusion PCT has important reference value in early clinical diagnosis of bacterial infection. Dynamic observation of PCT level during treatment can judge the curative effect and prognosis. CRP has certain reference value in assisting diagnosis of children’s infection, but its detection rate and sensitivity are lower than that of PCT group compared with PCT group.