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服用前列腺素(PG)E_2和F_(2α)可引起恶心、呕吐、腹绞痛、腹胀和腹泻等胃肠道症状。内源性PG则常可引起霍乱以及溃疡性结肠炎腹泻和其他的胃肠道症状。而PG合成抑制剂能有效地减轻溃疡性结肠炎腹泻和放射线照射后的综合征,同时对小肠假性梗阻也可能有效。作者观察了六例住院病人因摄入某些特异食物(如淡菜、鸡肉或猪肉、乳制品、蛋、甜玉米和柑桔类水果等)后所发生的急性胃肠道症状颇似接受PG病人的药物反应。因而进行了一次简单的临床试验,以估价PG合成抑制剂的预防效果。
Taking prostaglandin (PG) E_2 and F_ (2α) can cause nausea, vomiting, abdominal cramps, bloating and diarrhea and other gastrointestinal symptoms. Endogenous PG often causes cholera and ulcerative colitis diarrhea and other gastrointestinal symptoms. The PG synthesis inhibitors can effectively reduce ulcerative colitis diarrhea and radiation after the syndrome, while the intestinal pseudo-obstruction may also be effective. The authors observed that acute gastrointestinal symptoms in six inpatients that occurred following ingestion of specific foods such as mussels, chicken or pork, dairy products, eggs, sweet corn and citrus fruits were similar to those in PG Patient’s drug response. Thus, a simple clinical trial was conducted to evaluate the prophylactic effect of PG synthesis inhibitors.