论文部分内容阅读
本研究利用雷公藤醋酸乙酯（ＴＷＨ）提取物在同种大鼠肾移植中的应用，观察其作为免疫抑制剂在肾移植中的抗排斥效能，并使之与常用的免疫抑制剂硫唑嘌呤比较。实验结果表明：ＴＷＨ提取物及硫唑嘌呤均能明显延长大鼠肾移植物的存活时间，两组间受体存活时间无显著差异；ＴＷＨ提取物对受体外周血淋巴细胞化学发光的抑制程度与硫唑嘌呤相当；对外周血Ｔ淋巴细胞的影响前者抑制ＣＤ３、ＣＤ４的增生，增加ＣＤ８数目，后者对ＣＤ３、ＣＤ４及ＣＤ８均抑制；毒副反应观察硫唑嘌呤对肝脏损害及其减少血白细胞总数的作用较ＴＷＨ提取物明显；ＴＷＨ提取物在治疗剂量范围内对受体肾功能无明显影响。结论是：ＴＷＨ提取物在同种肾移植中的总体作用优于免疫抑制剂硫唑嘌呤。
In this study, the use of Tripterygium wilfordii ethyl acetate (TWH) extract in the same kind of rat kidney transplantation, its anti-rejection efficacy as an immunosuppressive agent in renal transplantation, and make it with the commonly used immunosuppressant thiazole Purine comparison. The experimental results show that both TWH extract and azathioprine can significantly prolong the survival time of rat renal allografts, there is no significant difference in the survival time of the two groups; TWH extracts inhibit the chemiluminescence of peripheral blood lymphocytes And azathioprine; Peripheral blood T lymphocytes The former inhibited the proliferation of CD3, CD4, increasing the number of CD8, the latter of CD3, CD4 and CD8 were inhibited; azathioprine toxic side effects observed on the liver damage and reduce The effect of total white blood cell count was more pronounced than that of TWH extract; TWH extract had no significant effect on renal function of recipients within the therapeutic dose range. The conclusion is that the overall effect of TWH extract on allografts is superior to the immunosuppressive agent azathioprine.