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目的:比较综合治疗和盐酸纳洛酮与山莨菪碱联合治疗高原肺水肿的疗效。方法:把2005年9月—2010年11月收治的62例患者随机分成两组,对照组30例,治疗组32例。对照组综合治疗中的血管扩张剂使用酚妥拉明,5mg~10mg稀释于5%葡萄糖100mL缓慢静点。治疗组综合治疗中的血管扩张剂用山莨菪碱10mg静推,根据病情(10~30)min-1,连用(3~5)次,并同时加用纳洛酮,首剂静脉注射(0.4~0.8)mg,之后每半小时给0.4mg,连用3次后每隔6小时用1次,连续使用8次。治疗组及对照组62例患者均痊愈出院,两组无1例死亡,治愈率为100%,治疗组平均住院天数(3±0.4)天,对照组平均住院天数(6±0.2)天。结论:盐酸纳洛酮与山莨菪碱救治高原肺水肿疗效肯定,见效快,缩短了平均住院天数。
Objective: To compare the curative effect of combination therapy and naloxone hydrochloride and anisodamine in the treatment of high altitude pulmonary edema. Methods: Sixty-two patients admitted from September 2005 to November 2010 were randomly divided into two groups: control group (30 cases) and treatment group (32 cases). The vasodilator in the control group was treated with phentolamine, and 5 mg ~ 10 mg diluted slowly in 100 mL of 5% glucose. In the treatment group, the vasodilators in the comprehensive treatment were intravenously injected with 10mg of anisodamine (n = 30) according to the condition of (10-30) min-1 for 3 to 5 times and naloxone plus ~ 0.8) mg, and then every 0.4 hours to 0.4mg, once every 6 hours for 3 times, 8 times in a row. Sixty-two patients in the treatment group and control group were cured and discharged. No one died in either group. The cure rate was 100%. The average length of stay in the treatment group was (3 ± 0.4) days. The mean length of stay in the control group was (6 ± 0.2) days. CONCLUSION: Naloxone hydrochloride and anisodamine are effective in treating pulmonary edema in high altitude, with quick effect and shortened average hospitalization days.