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目的 :研究健脾理气颗粒对大鼠胃溃疡及胃粘膜损伤的作用。方法 :采用水浸应激致胃溃疡及口服乙醇致胃粘膜损伤法制模 ,再用健脾理气颗粒 3个剂量组进行药效评价 ,并设对照组进行比较。结果 :健脾理气颗粒 3个剂量组对大鼠应激性胃溃疡的形成有明显的抑制作用 (P <0 .0 5～ 0 .0 1) ,对口服乙醇致胃粘膜损伤也有保护作用 ,尤以 10 g/ kg、2 0 g/ kg组为明显 (P <0 .0 5～ 0 .0 1)。结论 :健脾理气颗粒具有明显地抑制大鼠胃溃疡及保护胃粘膜损伤作用
Objective: To study the effect of Jianpi Liqi Granule on gastric ulcer and gastric mucosal injury in rats. Methods :Using water immersion stress induced gastric ulcer and oral ethanol induced gastric mucosa injury model, and then three groups of Jianpi Qiqi particles for efficacy evaluation, and set the control group for comparison. RESULTS: Three doses of Jianpi Qiqi Granules had significant inhibitory effect on the formation of stress gastric ulcer in rats (P 0.05-0.01), which also protected gastric mucosal injury caused by oral ethanol. Especially in the 10 g/kg and 20 g/kg groups (P < 0.05 to 0.01). Conclusion :Jianpi Liqi Granules can significantly inhibit gastric ulcer and protect gastric mucosal damage in rats