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本文以地方性氟中毒病区51名孕妇及其引产胎儿为研究对象。用氟电极法检测母体尿、血、脐带血、羊水的氟水平。同时对51例胎儿股骨全部进行了光镜观察,并分析了不同氟水平下胎儿股骨的病理改变率。结果表明,胎儿股骨的病理改变率随母体尿、血、羊水的氟水平增加而升高。当尿氟低于1.8ppm、母血氟低于0.93ppm、羊水氟低于0.018ppm 时,无胎儿股骨病理改变发生。当母尿氟高于4.0ppm、血氟高于1.3ppm、羊水氟高于0.07ppm 时,病理改变率分别为66.7%,63.2%,61.1%,RR 值各为12.7,7.6和5.5。研究结果提示,胎儿股骨病理改变率受母体氟水平影响,故可以用母体氟水平估测氟对胎儿有无影响。
In this paper, 51 cases of endemic fluorosis ward and its fetus fetus as the research object. Fluoride electrode method to detect maternal urine, blood, umbilical cord blood, amniotic fluid fluoride levels. At the same time, 51 cases of fetal femur were observed by light microscopy, and analyzed the pathological changes of fetal femur under different fluoride levels. The results showed that the pathological changes of fetal femur with the mother urine, blood, amniotic fluid levels of fluoride increased. When urinary fluoride less than 1.8ppm, less than 0.93ppm maternal serum fluoride, amniotic fluid fluoride less than 0.018ppm, no fetal femoral pathological changes occurred. When the urinary fluoride was higher than 4.0ppm, blood fluoride was higher than 1.3ppm, amniotic fluid fluorine was higher than 0.07ppm, the pathological changes were 66.7%, 63.2% and 61.1% respectively. The RR values were 12.7, 7.6 and 5.5 respectively. The results suggest that fetal fibroblast pathological changes rate affected by the level of maternal fluorine, it can be used to assess the level of fluoride on the fetus fluoride.