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结核病(TB)的化疗,特别是近年来短程化疗的成功开创了TB治疗的新纪元。目前,短程化疗治疗肺TB已得到广泛的接受,但是在泌尿男生殖系结核(UGTB)的治疗中,短程化疗并没有受到应有的重视,UGTB的化疗很不正规,常常导致耐药菌株的出现和疾病的复发与恶化。为了提高UGTB的治愈率,减少药物的毒性反应,本文简要介绍UGTB短程化疗及与其有关的问题。 TB化疗的演变:有效的杀菌和抑菌药物的发现是TB化疗进展的关键。在1943年链霉素(S)问世以前,TB的疫情遍世界各地,无情吞噬亿万人民
Chemotherapy for tuberculosis (TB), especially the success of short-course chemotherapy in recent years, opens up a new era of TB therapy. At present, the treatment of lung TB by short-course chemotherapy has been widely accepted, but in the treatment of urinary and male genital TB (UGTB), short-course chemotherapy has not received the attention it deserves. Chemotherapy of UGTB is very irregular, often resulting in Emergence and disease recurrence and deterioration. In order to improve the cure rate of UGTB and reduce the toxicity of drugs, this article briefly introduces the short-course chemotherapy of UGTB and its related problems. The Evolution of TB Chemotherapy: Effective sterilization and the discovery of bacteriostatic drugs are key to the progress of TB chemotherapy. Before the advent of streptomycin (S) in 1943, the outbreak of TB spread all over the world, relentlessly engulfing hundreds of millions of people