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例1:男,42岁。入院诊断精神分裂症,体检正常。给予氟哌啶醇10mg/d,海俄辛0.6mg/d,im。ld后出现发热,T40℃,意识朦胧。体检:瞳孔直径2.5mm,等大,光反射正常,眼底正常。全身多汗,P120次/min,呼吸浅快,R 31次/min,两肺呼吸音清晰。全身肌张力增高,肢体强直,腱反射活跃,对称,未引出病理反射。实验室检查:WBC 8.5X10~9/L,血清CPK 1220U/L,EKG正常。诊断为恶性综合征。即停抗精神病药物,给溴隐亭22.5mg/d,同时予抗感染,降温,补液等对症处理,患者逐渐恢复意识,
Example 1: Male, 42 years old. Admission diagnosis of schizophrenia, physical examination was normal. Given haloperidol 10mg / d, sea Russoxin 0.6mg / d, im. After ld fever, T40 ℃, consciousness dim. Physical examination: pupil diameter 2.5mm, such as large, normal light reflex, fundus normal. General sweating, P120 times / min, shallow breathing fast, R 31 times / min, both lungs breath sounds clear. Systemic muscle tone increased, limb stiffness, tendon reflexes active, symmetrical, did not lead to pathological reflex. Laboratory tests: WBC 8.5X10 ~ 9 / L, serum CPK 1220U / L, EKG normal. Diagnosis of malignant syndrome. That stop antipsychotic drugs to bromocriptine 22.5mg / d, at the same time to anti-infection, cooling, fluid replacement symptomatic treatment, the patient gradually restored consciousness,