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对急性淋巴细胞白血病(ALL)儿童进行中枢神经系统(CNS)白血病预防的最常用方法是联合应用化疗药物鞘内注射与脑放射。但用此法后,即使在无症状患儿中也有50～60%呈C.T.扫描异常,还可有智力迟钝。作者改用鞘注氨甲蝶呤(MTX)与静注大剂量MTX(HDM)合用,并研究采用这种不包括脑放射的CNS预防后,ALL患儿的C.T.改变。病人和方法:3～14岁ALL原发缓解患儿共19例,于CNS预防治疗结束后2～64个月进行脑C.T.扫描研究。另有3例6～14岁ALL伴CNS白血病患儿,在
The most common method of prevention of central nervous system (CNS) leukemia in children with acute lymphoblastic leukemia (ALL) is the combination of chemotherapy with intrathecal and brain irradiation. However, with this method, even in asymptomatic children also have 50 ~ 60% were abnormal C.T. scan, but also have mental retardation. The authors used intrathecal methotrexate (MTX) in combination with intravenous bolus MTX (HDM) and studied C.T. changes in ALL children using this CNS-free prophylaxis of brain radiation. PATIENTS AND METHODS: A total of 19 ALL children aged 3-14 years were followed up for brain CT scan 2 to 64 months after the prophylaxis of CNS. Another 3 patients aged 6 to 14 years with ALL children with CNS leukemia in