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目的探讨二甲基甲酰胺职业暴露与作业人员慢性非萎缩性胃炎的相关性。方法对4家企业385名员工进行健康状况调查,将发现的28例慢性非萎缩性胃炎现患者设为病例组,所有对象经性别、年龄排序后,按性别一致、年龄±1岁分组,在每个病例对应的组中,统一依次按“隔位选一”原则选取4名无现患者(1∶4配对),共112名工人为对照组,开展病例对照研究。相关性分析与评价采用卡方检验和条件Logistic回归分析。结果 (1)慢性非萎缩性胃炎现患率在性别上基本保持一致,但在年龄分组上存在一定差异(P<0.05);(2)病例组二甲基甲酰胺接触率显著高于对照组,接触工龄≤5年者尤为突出(P<0.05);(3)调整吸烟、饮酒和其他职业病危害因素接触等混杂因素后,二甲基甲酰胺接触与患慢性非萎缩性胃炎的危险性增加显著相关,接触二甲基甲酰胺≤5年患慢性非萎缩性胃炎的危险较明显(P<0.05)。结论二甲基甲酰胺职业暴露可增加患慢性非萎缩性胃炎的危险。
Objective To investigate the correlation between dimethylformamide occupational exposure and chronic non-atrophic gastritis in workers. Methods The health status of 385 employees in 4 enterprises was investigated. Twenty-eight cases of chronic non-atrophic gastritis were found as case group. All subjects were classified according to sex and age by age and sex, In each case, four non-present patients (1: 4 pairs) were randomly selected according to the principle of “choosing one place at a time”. A total of 112 workers were selected as the control group to conduct a case-control study. Correlation analysis and evaluation using the chi-square test and conditional Logistic regression analysis. Results (1) The prevalence of chronic non-atrophic gastritis was basically the same in sex, but there were some differences in age group (P <0.05). (2) The contact rate of dimethylformamide in case group was significantly higher than that in control group (P <0.05). (3) The risk of exposure to dimethylformamide and chronic non-atrophic gastritis were significantly increased after adjusting for such confounders as smoking, drinking and other occupational hazards , The risk of chronic non-atrophic gastritis was significantly higher than that of dimethylformamide ≤5 years (P <0.05). Conclusion Dimethylformamide occupational exposure may increase the risk of chronic non-atrophic gastritis.