卵巢癌目前仍是病死率最高的妇科恶性肿瘤 ,肿瘤的局部侵袭和弥漫的腹腔内转移是卵巢癌患者治疗失败和死亡的直接原因。肿瘤的侵袭转移是一复杂的、多步骤的肿瘤细胞与宿主细胞及基质间相互作用的过程 ,但肿瘤细胞对细胞外基质的破坏是肿瘤细胞侵袭转移的基本模式。在卵巢癌侵 Ovarian cancer is still the highest mortality rate of gynecological malignancies, local tumor invasion and peritoneal metastasis of ovarian cancer is the direct cause of treatment failure and death. Invasion and metastasis of tumor is a complex and multi-step process of tumor cells interacting with host cells and matrix. However, the destruction of extracellular matrix by tumor cells is the basic pattern of tumor cell invasion and metastasis. Invasion of ovarian cancer