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口腔颌面部上皮来源的肿瘤主要包括口腔粘膜癌(常见的如口腔鳞癌、舌癌等)、涎腺的上皮性肿瘤(常见的如涎腺混合瘤、粘液表皮样癌和腺样囊性癌等)以及牙源性上皮性肿瘤(常见的如成釉细胞瘤和牙源性角化囊性瘤等)。肿瘤的发生与细胞的凋亡、增殖和肿瘤的血管生成关系密切,而环氧化酶-2(Cyclooxygenase-2,COX-2)在这些方面发挥着重要的作用。一、COX-2的结构与功能哺乳动物的环氧化酶(cyclooxygenase,COX)有
Oral and maxillofacial epithelial tumors mainly include oral mucosal cancer (common, such as oral squamous cell carcinoma, tongue cancer, etc.), salivary gland epithelial tumors (common such as salivary gland mixed tumor, mucoepidermoid carcinoma and adenoid cystic Cancer, etc.) as well as odontogenic epithelial tumors (common such as ameloblastoma and odontogenic keratocystic tumors, etc.). The occurrence of tumor is closely related to apoptosis, proliferation and angiogenesis of tumor cells. Cyclooxygenase-2 (COX-2) plays an important role in these aspects. First, the structure and function of COX-2 Mammalian cyclooxygenase (cyclooxygenase, COX) there