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由小鼠体内分布资料估算N-氨水(13N-NH3?H2O)在人体内辐射吸收剂量,并评价其安全性。由小鼠13尾静脉注射N-NH3?H2O后,在0、0.5、1、2、5、10、20、30min时刻处死动物,测定小鼠体内各脏器放13射性分布,换算至标准人体内分布数据,按MIRD法计算人体内N-NH3?H2O辐射吸收剂量。经估算,人体13肝内照射吸收剂量最高,其值为3.6×10-3mGy/MBq,全身内照射吸收剂量最低,约为1.7×10-3mGy/MBq,其他脏器内照射吸收剂量在(2.4—3.3)×10-3mGy/MBq之间,有效剂量为1.8×10-3mSv/MBq。由小鼠体内分布资料可估算人体内N-NH3?H2O吸收剂量,这些资料为临床安全应用N-NH3?H2O提供了依据。1313
The radiation absorbed dose of N-ammonia (13N-NH3? H2O) in human was estimated from the in vivo distribution in mice and its safety was evaluated. Animals were sacrificed at 0, 0.5, 1, 2, 5, 10, 20 and 30 minutes after injection of N-NH3? H2O from the tail vein of mice. The radioactivity distribution of each organ in mice was measured and converted to standard Human body distribution data, according to MIRD method to calculate the human body N-NH3? H2O radiation absorbed dose. It is estimated that the highest dose of intrahepatic radiation absorbed by human body 13 is 3.6 × 10-3mGy / MBq, and the lowest absorbed dose is 1.7 × 10-3mGy / MBq in the whole body. The absorbed dose in other organs is 2.4 -3.3) × 10 -3 mGy / MBq, and the effective dose is 1.8 × 10 -3 mSv / MBq. In vivo data from mice can be used to estimate the amount of N-NH3-H2O absorbed in the human body. These data provide the basis for the safe use of N-NH3-H2O in clinical practice. 1313