自1940年青霉素问世以来,有人即研究了其注入眼内的疗效和毒性。Leopold和Scheie最早证明,玻璃体内注射磺胺作用不大,而在细菌接种后6—12小时给予青霉素玻璃体内注射,可以控制实验性玻璃体内感染。青霉素在玻璃体内维持有效浓度达24—48小时,但房水内浓度很低,12—16小时后 Since the advent of penicillin in 1940, some have studied the efficacy and toxicity of injecting penicillin. Leopold and Scheie were the first to demonstrate that intravitreal injection of sulfanilamide is not effective and that intravitreal injection of penicillin 6 to 12 hours after bacterial inoculation can control experimental vitreous infection. Penicillin in the vitreous to maintain an effective concentration of 24-48 hours, but the aqueous humor concentration is very low, 12-16 hours later