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目的研究家兔膀胱体表肌电与膀胱内压在贮尿和排尿期的变化及两者之间关系并评估其临床价值。方法雄性家兔3只,从家兔耳缘静脉输注生理盐水,将一对记录电极纵向固定于膀胱正中体表部位,参考电极固定于一侧大腿根部,3个电极与RM6240生物信号采集系统1通道相连测膀胱肌电;用导尿管经尿道插入膀胱,其出口通过压力换能器与RM6240系统2通道相连测膀胱内压;RM6240系统同时记录排尿过程中两者变化。每只家兔每次实验观察10个排尿周期,每3d重复1次实验,重复4次。结果贮尿期膀胱内压基本稳定,未见明显膀胱肌电。随着膀胱内尿液增多,膀胱内压缓慢上升,达到(36.4±5.9)cmH20时突然快速上升达到峰值,随后迅速下降至基线水平;膀胱内压升高同时可见排尿及呈爆发样幅度不一的双相膀胱肌电。压力峰值和肌电平均峰值、频率的相关系数分别为r1=0.803(P<0.05)、r2=0.254(P<0.05),压力峰值时间稍迟于肌电峰值时间,延迟约(0.12±0.10)s,两者相关系数为r3=1(P<0.05);压力上升时限和肌电时限无明显差异(P>0.05),相关系数为r4=0.757(P<0.05)。结论体表可检测到膀胱肌电信号,膀胱体表肌电信号与膀胱内压密切相关,可直接反应膀胱逼尿肌的收缩功能,具有重要临床价值。
Objective To study the changes of bladder electromyography and bladder pressure during storage and urination in rabbits and the relationship between them and to evaluate their clinical value. Method 3 male rabbits, rabbit ear vein from the saline infusion, the pair of longitudinal recording electrode is fixed to the middle body portion of the bladder, the reference electrode is fixed to one side of the thigh, and three electrodes RM6240 biological signal acquisition system 1 channel connected measured bladder electromyography; urethral catheter inserted into the bladder through the urethra, the outlet through the pressure transducer connected to the RM6240 system 2 channel measurement of intravesical pressure; RM6240 system while recording urinary changes in both. Each rabbit observed in each experiment 10 voiding cycles, repeated once every 3d experiments, repeated 4 times. Urinary bladder pressure during storage was basically stable, no significant bladder electromyography. With the increase in the urinary bladder, intravesical pressure gradually rose and reached (36.4 ± 5.9) cmH20 sudden rapid rise to peak time, and then rapidly decreased to baseline levels; micturition pressure is increased while the visible and varying magnitudes like explosively Biphasic bladder EMG. EMG and mean peak pressure peaks, frequency correlation coefficients were r1 = 0.803 (P <0.05), r2 = 0.254 (P <0.05), a pressure peak time slightly later than peak EMG time delay of about (0.12 ± 0.10) s. The correlation coefficient between them was r3 = 1 (P <0.05). There was no significant difference between the rising time of pressure and the time of EMG (P> 0.05). The correlation coefficient was r4 = 0.757 (P <0.05). Conclusion The body surface can detect the signal of bladder EMG. The signal of bladder EMG is closely related to the internal pressure of the bladder. It can directly reflect the contractile function of bladder detrusor muscle and has important clinical value.