研究对象 年龄21至75岁,静息时发生心绞痛≥30分钟但<6小时并有明确的心电图改变:新发生的相邻2个或以上导联ST段抬高≥0.1mV或新出现的左束支传导阻滞且无溶栓治疗反指征。 方法 在链激酶(1.5×10~6u)和阿斯匹林(325mg/日)治疗前先随机静注肝素或水蛭素,此后连用5天直至设定的试验终点。肝素首剂5000u+1000u/h(n=71)。水蛭素 Participants were 21 to 75 years of age with angina pectoris ≥30 minutes at rest but <6 hours with definite ECG changes: ST-segment elevation ≥0.1 mV in newly-occurring adjacent leads or ≥0.1 mV or emerging left Bundle branch block and thrombolytic therapy without anti-indications. Methods Heparin or hirudin was randomized before streptokinase (1.5 × 10 ~ 6u) and aspirin (325mg / day), and then used for 5 consecutive days until the set end of the trial. Heparin first dose 5000u + 1000u / h (n = 71). Hirudin