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目的:评价体外冲击波碎石术(ESWL)后坦索罗辛辅助输尿管结石患者排石的临床疗效。方法:72例输尿管结石患者随机分为观察组和对照组各36例,ESWL术后,对照组给予常规治疗,观察组在此基础上应用坦索罗辛0.2 mg,po,qd。两组均治疗4周。比较两组患者术后3,7,14,28 d后的结石排净率、结石排净平均时间、肾绞痛发生率及VAS评分情况。结果:观察组术后3,7d时的结石排净率与对照组同期对比差异无统计学意义(P>0.05);观察组14,28 d时的结石排净率均明显高于高于对照组(P<0.05);观察组的结石排净平均时间、肾绞痛发生率及VAS评分均显著低于对照组(P<0.05)。结论:坦索罗辛可有效促进ESWL术后碎石的排出,同时缓解疼痛,改善患者生活质量。
OBJECTIVE: To evaluate the clinical efficacy of tamsulosin-assisted ureteral calculi in patients undergoing extracorporeal shock wave lithotripsy (ESWL). Methods: Seventy-two patients with ureteral calculi were randomly divided into observation group (36 cases) and control group (36 cases). After ESWL, the control group was treated with conventional therapy. The observation group was given tamsulosin 0.2 mg, po, qd on the basis of this observation. Both groups were treated for 4 weeks. The stone clearance rate, the mean time of stone discharge, the incidence of renal colic and the VAS score were compared between the two groups after 3, 7, 14 and 28 days. Results: The stone clearance rate of the observation group at 3 and 7 days after operation was not significantly different from that of the control group at the same period (P> 0.05). The stone clearance rate of the observation group at 14 and 28 days was significantly higher than that of the control (P <0.05). The mean time to stone discharge, the incidence of renal colic and the VAS score in the observation group were significantly lower than those in the control group (P <0.05). Conclusion: Tamsulosin can effectively promote the discharge of gravel after ESWL, relieve pain and improve the quality of life of patients.